Individual skill
science-signaling
Use when targeting Science Signaling (Sci. Signal.) or deciding whether a cell-signaling, systems-biology, or signaling-pharmacology manuscript fits this AAAS venue. Encodes the journal's fit, framing, method-and-evidence bar, house style, official-submission re-check, and desk-reject heuristics.
English-NaturalScience-Journal-Skills/skills/science-signaling/SKILL.md
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- Last checked
- Nov 9, 2026
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- Repository last updated
- Sep 27, 2026
- License
- MIT
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# Science Signaling (science-signaling)
## Journal positioning
Science Signaling, published by the American Association for the Advancement of Science (AAAS), is a leading journal dedicated to cellular signal transduction and its regulation in health and disease. Its defining character is mechanistic depth in signaling: it publishes primary research and reviews that elucidate how cells sense, transmit, integrate, and respond to information — receptor biology, kinase and phosphatase networks, second messengers, signaling crosstalk, and the systems-level behavior of signaling pathways. The journal rewards work that defines a new signaling mechanism, maps the dynamics or logic of a network, or connects signaling biology to physiology, disease, or pharmacology. Readership spans cell and molecular biologists, systems biologists, and pharmacologists. It is part of the Science family and carries that expectation of significance and rigor.
This skill is a **fit / venue-selection / re-framing** tool. It does not replace the journal's current official submission guidelines. Before submitting, re-check the live author instructions on the Science Signaling (AAAS) site.
## When to trigger
- The author names Science Signaling as the target for a mechanistic signal-transduction or systems-biology-of-signaling paper.
- A study defines a new signaling mechanism, network behavior, or pharmacological modulation of a pathway and the author is choosing between Science Signaling and `science-translational-medicine`, `cell-metabolism`, or a specialized signaling journal.
- A systems-biology paper models signaling-network dynamics and needs a venue that values both mechanism and quantitative analysis.
- The author needs Science Signaling's scope, evidence bar, and desk-reject criteria before submission.