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jama-statistics
Use when preparing or auditing the statistical analysis and reporting of a JAMA manuscript so it survives JAMA's dedicated statistical review. Enforces effect sizes with 95% CIs, multiplicity control, and pre-specification; it does NOT choose the study design or write prose.
JAMA-Skills/skills/jama-statistics/SKILL.md
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# Statistics & Statistical Review (jama-statistics)
## When to trigger
- Results report p-values without effect sizes or confidence intervals
- Many comparisons but no multiplicity plan
- The analysis was not pre-specified, or outcomes drifted from the protocol
- Preparing for JAMA's **dedicated statistical review** of accepted-pending manuscripts
## Core reporting rules at JAMA
1. **Effect sizes with 95% CIs, not p-values alone.** Report the estimate (mean difference, risk/hazard/odds ratio, absolute risk difference) **with its 95% CI**. P-values supplement; they do not substitute. Treat "significance" as a statement about the interval, not a 0.05 threshold ritual.
2. **Pre-specified outcomes.** State the single primary outcome and the secondary outcomes exactly as registered/protocoled. Flag any post hoc analysis as exploratory.
3. **Intention-to-treat for RCTs.** Primary analysis is ITT; per-protocol and as-treated are secondary/sensitivity.