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nature-structural-and-molecular-biology

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Use when targeting Nature Structural & Molecular Biology (NSMB) or deciding whether a structural/molecular biology manuscript fits this venue. Encodes the journal's fit, framing, method-and-evidence bar, house style, official-submission re-check, and desk-reject heuristics.

English-NaturalScience-Journal-Skills/skills/nature-structural-and-molecular-biology/SKILL.md

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# Nature Structural & Molecular Biology (nature-structural-and-molecular-biology)

## Journal positioning

Nature Structural & Molecular Biology is the Springer Nature specialist journal for research at the intersection of structure and function, covering proteins, nucleic acids, macromolecular complexes, and the mechanistic molecular biology they underpin. The journal is explicitly structure-function focused: high-resolution structural determination is expected to illuminate mechanism, conformational dynamics, or biology — not to be an end in itself. Readership spans structural biologists, biochemists, cell biologists, and biophysicists for whom atomic-level mechanism is a shared language. This skill is a **fit / venue-selection / re-framing** tool. It does not replace the journal's current official submission guidelines. Before submitting, re-check the live author instructions on the Springer Nature NSMB site and submission portal.

## When to trigger

- The author names NSMB as the target venue for a structure-function or mechanistic molecular-biology study.
- A cryo-EM, X-ray crystallography, NMR, or single-molecule manuscript needs evaluation for whether its biological insight clears the NSMB bar.
- A mechanistic molecular-biology paper lacking structural data is being considered alongside NSMB and sister journals (Molecular Cell, Nature Chemical Biology).
- The author needs NSMB's high-frequency desk-reject triggers and an alternative-venue list before submitting.

## Scope & topic fit
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