Menu

Individual skill

journal-of-clinical-investigation

0upvotes

Use when targeting Journal of Clinical Investigation (JCI) or deciding whether a translational medicine manuscript fits this venue. Encodes the journal's fit, framing, method-and-evidence bar, house style, official-submission re-check, and desk-reject heuristics.

English-NaturalScience-Journal-Skills/skills/journal-of-clinical-investigation/SKILL.md

Read pinned source

Source commit 932eb23331721b16e967c59f093781be1928b498

What was checked

Matches the observed repository HEAD
Yes
Scanner rules are current
No
Repository scan complete
No
Skill scan complete
Yes
Observed behavior
Not checked yet
Last checked
Nov 9, 2026

These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.

Install this skill

Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.

An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.

Repository context

Repository stars (not skill ratings)
1,411
Repository last updated
Sep 27, 2026
License
MIT

Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.

Files and excerpt

File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.

Browse files
Read excerpt

# Journal of Clinical Investigation (journal-of-clinical-investigation)

## Journal positioning

The Journal of Clinical Investigation is published by the American Society for Clinical Investigation and is the flagship venue for disease-mechanism research that bridges fundamental biology and human medicine. JCI's defining editorial DNA is mechanism-of-disease with direct human or translational relevance: papers must deliver a clear mechanistic insight into a disease process — not merely a correlation or an association — and must ground that insight in human clinical samples, genetics, imaging, or biomarkers, with animal or in vitro models providing mechanistic depth rather than serving as the primary evidence. JCI occupies a distinct tier below the broad-significance bar of Nature Medicine or Cell but above society clinical journals; its readership is physician-scientists and translational researchers across all disease areas.

This skill is a **fit / venue-selection / re-framing** tool. It does not replace the journal's current official submission guidelines. Before submitting, re-check the live author instructions on the ASCI / JCI platform.

## When to trigger

- The author names JCI or the ASCI as the target venue for a disease-mechanism or translational manuscript.
- A mechanistic study of a disease process needs venue selection between JCI, Science Translational Medicine, and Nature Medicine.
- A paper with strong human-data primary evidence and mechanistic animal or in vitro support needs framing guidance.
- The author needs JCI's specific desk-reject risks and a ranked alternative-venue list before submitting.
Back to top