Individual skill

bioconductor-crisprdesign

Provides a comprehensive suite of functions to design and annotate CRISPR guide RNA (gRNAs) sequences. This includes on- and off-target search, on-target efficiency scoring, off-target scoring, full gene and TSS contextual annotations, and SNP annotation (human only). It currently support five types of CRISPR modalities (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition, CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported, including

skills/transcriptomics/crisprdesign/SKILL.md

Source commit c9bd4d8eb6edc5308a8f55e6184dce9e8afadf12

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Matches the observed repository HEAD

Yes

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Yes

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No

Skill scan complete

Yes

Observed behavior

Instructions only

Last checked

Nov 10, 2026

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