Individual skill

biomarker-discovery

Reason about biomarker discovery and validation in HCLS — classifying biomarker intent, choosing feature-selection and cross-validation strategies, avoiding leakage, and planning external replication. Use when the user asks to discover, develop, or validate a biomarker; select features from high-dimensional omics or clinical data; design a validation study; choose evaluation metrics; justify sample size; combine multi-omics signals; or assess clinical utility. Triggers include "discover a biomarker", "validate biomarker", "prognostic vs predictive", "feature selection", "LASSO vs elastic net", "nested cross-validation", "data leakage", "C-index", "time-dependent AUC", "decision curve analysis", "external validation cohort", "events per variable", "optimism-corrected", "multi-omics integration", "clinical utility of a biomarker", "is this biomarker ready".

skills/biomarker-discovery/SKILL.md

Source commit 4603541c396cdd845dbae554800a65132d12bb63

What was checked

Matches the observed repository HEAD

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Yes

Observed behavior

Local scripts

Last checked

Nov 11, 2026

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