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meta-analysis

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Use when running a systematic review and meta-analysis, DTA or intervention. Covers PROSPERO protocol, search, screening, extraction, risk of bias (QUADAS-3, RoB 2, ROBINS-I), bivariate/HSROC or random-effects pooling, forest plots, heterogeneity and PRISMA reporting. Topic scouting is /ma-scout.

skills/meta-analysis/SKILL.md

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# Meta-Analysis Skill

## Meta-Analysis Types

| Type | RoB Tool | Statistical Model | Reporting Guideline |
|------|----------|-------------------|-------------------|
| **DTA** (diagnostic test accuracy) | **QUADAS-3** (QUADAS-2 for legacy reviews) | Bivariate / HSROC | PRISMA-DTA |
| **Intervention** (treatment effect) | RoB 2 (RCT) / ROBINS-I (NRSI) | Random-effects (REML, Hartung-Knapp CI) | PRISMA 2020 |
| **Prognostic factor** (association of one factor with outcome) | QUIPS | Random-effects | PRISMA 2020 |
| **Prediction model** (model performance) | PROBAST | Random-effects | PRISMA 2020 |
| **Observational** (prevalence/association) | NOS / JBI | Random-effects | MOOSE |

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