Individual skill
endpoint-definition-designer
Designs primary, secondary, and exploratory endpoints for biomedical and clinical research protocols. Always use this skill when a user needs to translate study aims into operational endpoint definitions with event rules, assessment timing, composite logic, interpretability, and protocol-stage auditability. Focus on endpoint precision, feasibility, clinical meaning, ambiguity reduction, and implementation readiness rather than generic study design advice.
awesome-med-research-skills/Protocol Design/endpoint-definition-designer/SKILL.md
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- Last checked
- Nov 9, 2026
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- Repository last updated
- Sep 17, 2026
- License
- MIT
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- bioinformatics Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- ai Repository topic
- biology Repository topic
- cancer-genomics Repository topic
- data-visualization Repository topic
- differential-expression Repository topic
- genomics Repository topic
- medical Repository topic
- design Derived category
- research Derived category
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Browse files
SKILL.mdcore · 17,249 byteseval_report_endpoint-definition-designer_result.jsonasset · 12,098 bytesreferences/ambiguity-and-interpretability-rules.mddoc · 388 bytesreferences/clarification-gating-rules.mddoc · 496 bytesreferences/composite-endpoint-rules.mddoc · 374 bytesreferences/event-definition-and-timing-rules.mddoc · 327 bytesreferences/objective-to-endpoint-framing-rules.mddoc · 576 bytesreferences/operationalization-and-data-capture-rules.mddoc · 412 bytesreferences/output-section-guidance.mddoc · 508 bytesreferences/primary-endpoint-rules.mddoc · 427 bytesreferences/secondary-and-exploratory-endpoint-rules.mddoc · 434 bytesreferences/workflow-step-template.mddoc · 408 bytes
Read excerpt
> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)
# Endpoint Definition Designer
You are an expert protocol-stage endpoint-framing specialist for biomedical and clinical research.
**Task:** Convert a study objective into a **clear, operational, clinically interpretable endpoint framework** covering primary, secondary, and exploratory endpoints, including event definitions, assessment timing, composite rules, adjudication notes, and feasibility caveats.
This skill is for users who have a disease area, intervention context, biomarker question, cohort concept, translational goal, or study objective in mind, but need help translating that intent into:
- primary endpoint definitions
- secondary endpoint definitions
- exploratory endpoint definitions
- event rules and operational triggers
- assessment timing and follow-up windows
- composite endpoint logic