Individual skill
two-sample-mr-research-planner
Generates complete two-sample Mendelian randomization (MR) research designs from a user-provided research direction. Use when users want to design, plan, or build a study using two-sample MR to test causal relationships. Triggers:"design a two-sample MR study", "build a publishable MR paper", "test whether this biomarker causally affects this disease", "generate Lite/Standard/Advanced MR plans", "screen multiple exposures with MR", "bidirectional MR design", "causal inference using GWAS summary statistics", or "I want to study X and Y using MR". Always outputs four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path.
scientific-skills/Protocol Design/two-sample-mr-research-planner/SKILL.md
Source commit 686e09dfdb45d9fa1a08664f06bb93769b3c9d91
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- No
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Not checked yet
- Last checked
- Nov 9, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
Install this skill
Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.
An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.
Repository context
- Repository stars (not skill ratings)
- 2,048
- Repository last updated
- Sep 17, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- bioinformatics Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- ai Repository topic
- biology Repository topic
- cancer-genomics Repository topic
- data-visualization Repository topic
- differential-expression Repository topic
- genomics Repository topic
- medical Repository topic
- research Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Browse files
SKILL.mdcore · 11,020 bytesSKILL.mdcore · 11,020 byteseval_report_two-sample-mr-research-planner_polished_result.jsonasset · 12,479 bytesreferences/gwas_databases.mddoc · 4,717 bytesreferences/iv_benchmarks.mddoc · 4,549 bytes
Read excerpt
> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)
# Two-Sample Mendelian Randomization Research Planner
Generates a complete two-sample MR study design from a user-provided research direction. Always outputs four workload configurations and a recommended primary plan.
## Supported Study Styles
| Style | Description | Example |
|-------|-------------|---------|
| **A. Single Exposure → Single Outcome** | One biomarker or trait to one disease | Serum uric acid → gout; vitamin D → osteoporosis |
| **B. Multi-Exposure Screening** | Panel of exposures to one outcome | Dietary factors → endometriosis; cytokine panel → RA |
| **C. Bidirectional MR** | Reciprocal causal testing | Inflammation ↔ depression; BMI ↔ osteoarthritis |
| **D. Lifestyle / Diet / Behavioral** | Self-reported behavioral exposures | Coffee intake → hypertension; sleep duration → stroke |
| **E. Biomarker / Molecular Trait** | Circulating proteins, metabolites | Cytokines → autoimmune disease; plasma proteins → Alzheimer's |