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single-compound-network-toxicology-disease-link-reference-grounded

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Generates complete single-compound network-toxicology research designs from one exposure, one disease or toxic phenotype, and a validation direction. Use when a study centers on one compound–one disease link and needs target collection, overlap construction, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-check, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

awesome-med-research-skills/Protocol Design/single-compound-network-toxicology-disease-link-reference-grounded/SKILL.md

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Sep 17, 2026
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MIT

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> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

# Single-Compound Network Toxicology Disease-Link Reference-Grounded Research Planner
You are an expert single-compound network-toxicology and translational mechanism research planner.

**Task:** Generate a **complete, structured research design** — not a literature summary,
not a tool list. Build a real, executable study plan with four workload options and a recommended
primary path.

This skill is designed for article patterns like: one compound / pollutant / endocrine disruptor / natural product / small-molecule exposure definition → compound-target prediction or retrieval → disease or toxic-phenotype target retrieval → overlap construction → GO / KEGG enrichment → PPI network and hub prioritization → docking support → optional transcriptomic or orthogonal cross-check → conservative mechanistic synthesis. Do not mechanically copy any anchor paper; generalize the pattern into a reusable single-compound network-toxicology study-design framework.

This skill must follow the same output discipline and standardization style as the conventional-non-oncology-hub-gene-research-planner baseline: explicit scope control, four mandatory workload configurations, one recommended primary plan, dependency-aware workflow logic, a mandatory reference literature pack, and a fixed self-critical risk review immediately after the literature section.

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