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elastic-net-feature-selection

Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path and cross-validation plots. Trigger keywords: elastic net, glmnet, feature selection, binary classification, lambda.min, lambda.1se. NOT for: survival/Cox modeling, multiclass outcomes, single-cell data, or non-expression tables.

awesome-med-research-skills/Data Analysis/elastic-net-feature-selection/SKILL.md

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# Elastic Net Feature Selection

## When to Use

- Use this skill for binary case-vs-control classification on bulk expression matrices.
- Use it when you need elastic net logistic regression feature selection, coefficient paths, and `cv.glmnet`-based lambda selection.
- Use custom labels such as `Tumor` and `Normal` only when the group file still contains exactly two outcome levels.

## Out of Scope

- Survival or Cox modeling
- Multiclass outcomes
- Single-cell data
- Non-expression tables
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