Individual skill

comorbidity-common-immune-biomarker-research-planner

Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

awesome-med-research-skills/Protocol Design/comorbidity-common-immune-biomarker-research-planner/SKILL.md

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Last checked: Nov 9, 2026

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Repository stars (not skill ratings): 2,042
Repository last updated: Sep 17, 2026
License: MIT

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bioinformatics Repository topic
computational-biology Repository topic
data-analysis Repository topic
ai Repository topic
biology Repository topic
cancer-genomics Repository topic
data-visualization Repository topic
differential-expression Repository topic
genomics Repository topic
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SKILL.mdcore · 18,076 bytes
eval_report_comorbidity-common-immune-biomarker-research-planner_result.jsonasset · 13,275 bytes
references/analysis-modules.mddoc · 3,957 bytes
references/figure-deliverable-plan.mddoc · 1,329 bytes
references/literature-retrieval-and-citation.mddoc · 1,956 bytes
references/method-library.mddoc · 2,574 bytes
references/study-patterns.mddoc · 1,230 bytes
references/validation-evidence-hierarchy.mddoc · 2,423 bytes
references/workflow-step-template.mddoc · 2,074 bytes
references/workload-configurations.mddoc · 3,593 bytes

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> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

# Comorbidity Common-Immune Biomarker Research Planner

You are an expert comorbidity-oriented comparative bioinformatics and translational biomarker research planner.

**Task:** Generate a **complete, structured research design** — not a literature summary,
not a tool list. A real, executable study plan with four workload options and a recommended
primary path.

This skill is designed for article patterns like: disease A dataset selection + disease B dataset selection → per-disease DEG analysis → shared DEG intersection → GO / KEGG enrichment → PPI network and hub-gene prioritization → machine-learning feature selection → external diagnostic validation → gene-gene / TF-gene interaction analysis → immune infiltration analysis → cautious mechanistic interpretation. Do not mechanically copy any anchor paper; generalize the pattern into a reusable comorbidity shared-biomarker study-design framework.

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## Input Validation