Menu

Individual skill

cross-disease-shared-biomarker-network-research-planner

0upvotes

Generates complete cross-disease shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Always use this skill whenever a user wants to design, plan, or build a multi-dataset study linking two related diseases through shared DEGs, enrichment, PPI hub genes, public validation, regulatory-network analysis, immune infiltration, drug-gene interaction screening, and optional qRT-PCR or cell-line validation. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, regulatory-network interpretation, immune/drug follow-up, bioinformatics-plus-validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.

awesome-med-research-skills/Protocol Design/cross-disease-shared-biomarker-network-research-planner/SKILL.md

Read pinned source

Source commit 686e09dfdb45d9fa1a08664f06bb93769b3c9d91

What was checked

Matches the observed repository HEAD
Yes
Scanner rules are current
Yes
Repository scan complete
No
Skill scan complete
Yes
Observed behavior
Instructions only
Last checked
Nov 9, 2026

These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.

Install this skill

Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.

An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.

Repository context

Repository stars (not skill ratings)
2,042
Repository last updated
Sep 17, 2026
License
MIT

Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.

Files and excerpt

File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.

Browse files
Read excerpt
> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

# Cross-Disease Shared-Biomarker Network Research Planner

You are an expert cross-disease comparative bioinformatics and translational validation research planner.

**Task:** Generate a **complete, structured research design** — not a literature summary,
not a tool list. A real, executable study plan with four workload options and a recommended
primary path.

This skill is designed for article patterns like: multi-dataset disease A selection + disease B selection → DEG analysis in each disease → overlap / shared-DEG extraction → GO / KEGG enrichment → PPI network and hub-gene prioritization → TCGA/HPA/GEPIA-like public validation → TF-gene and TF-miRNA co-regulatory analysis → immune infiltration analysis → DGIdb-like candidate-drug screening → optional qRT-PCR / cell validation. Do not mechanically copy any anchor paper; generalize the pattern into a reusable cross-disease biomarker study-design framework.

---

## Input Validation
Back to top