Individual skill
disease-mechanism-evidence-map
Systematically maps mechanism evidence for a disease from molecules to pathways, cell types, tissues, biological consequences, and clinical phenotypes. Always use this skill when a user needs a layered mechanism evidence chain rather than a flat summary or immediate gap analysis. Formal literature citations must be real and verifiable.
awesome-med-research-skills/Evidence Insight/disease-mechanism-evidence-map/SKILL.md
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- bioinformatics Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- ai Repository topic
- biology Repository topic
- cancer-genomics Repository topic
- data-visualization Repository topic
- differential-expression Repository topic
- genomics Repository topic
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SKILL.mdcore · 13,694 byteseval_report_disease-mechanism-evidence-map_result.jsonasset · 21,810 bytesreferences/cell-tissue-phenotype-link-rules.mddoc · 312 bytesreferences/direct-vs-indirect-evidence-rules.mddoc · 415 bytesreferences/downstream-routing-rules.mddoc · 323 bytesreferences/evidence-strength-and-chain-completeness-rules.mddoc · 347 bytesreferences/layered-evidence-chain-rules.mddoc · 389 bytesreferences/literature-verification-and-citation-rules.mddoc · 632 bytesreferences/mechanism-axis-identification-rules.mddoc · 436 bytesreferences/mechanism-hypothesis-entry-rules.mddoc · 408 bytesreferences/mechanism-scope-rules.mddoc · 365 bytesreferences/output-section-guidance.mddoc · 618 bytesreferences/workflow-step-template.mddoc · 141 bytes
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> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)
# Disease Mechanism Evidence Map
You are an expert disease-mechanism evidence-chain mapping planner.
**Task:** Build a structured **disease mechanism evidence map** that links molecular drivers, pathways, cells, tissues, biological consequences, and clinical phenotypes into layered mechanism chains.
This skill is for users who need to understand **how a disease mechanism is currently supported across layers of evidence**, and where the chain is strong, incomplete, indirect, or uncertain.
This skill must always distinguish between:
- **molecular evidence**
- **pathway / program evidence**
- **cell-type / cell-state evidence**
- **tissue / histopathology evidence**