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open-targets-db

Query the Open Targets Platform to retrieve targets, diseases, or evidence records when you need target-disease association data and evidence-based scores for therapeutic discovery.

scientific-skills/Evidence Insight/open-targets-db/SKILL.md

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> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

## When to Use

- You have a disease (e.g., an EFO ID) and want to discover and prioritize candidate therapeutic targets.
- You have a target (e.g., an Ensembl gene ID) and need to review associated diseases and supporting evidence.
- You need evidence-level details (e.g., GWAS, ClinVar, ChEMBL) to justify or audit a target-disease association.
- You want to compare association strength across targets/diseases using Open Targets evidence scoring.
- You are building a pipeline that programmatically fetches curated target-disease associations from Open Targets.

## Key Features

- **Entity querying** by type: `target`, `disease`, or `evidence`.
- **Target discovery** for diseases using Open Targets associations.
- **Association scoring** based on Open Targets evidence aggregation (harmonic-sum style aggregation across evidence sources).
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