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pharmacogenomics-basics

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Pharmacogenomics in practice — key gene-drug pairs, phenotype translation, and clinical implementation.

skills/pharmacogenomics-basics/SKILL.md

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## Overview

pharmacogenomics-basics covers using genetic variation to guide drug therapy: the high-evidence
gene-drug pairs, translating genotypes to metabolizer phenotypes, and implementing testing in
clinical workflows. It focuses on what's actionable now — a small set of well-validated pairs —
rather than the polygenic future.

## When to use

- Learning the actionable gene-drug pairs (CPIC/DPWG guidelines).
- Translating genotypes to phenotypes: CYP2D6, CYP2C19, TPMT, DPYD activity scores.
- Preemptive vs reactive testing strategies.
- Interpreting pharmacogenomic test reports.
- Implementing: CDS alerts, EHR integration, result portability.
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