Individual skill
dose-response-analysis
Dose-response modeling — EC50 estimation, curve fitting, synergy analysis, and benchmark-dose methods.
skills/dose-response-analysis/SKILL.md
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## Overview
dose-response-analysis covers the quantitative relationship between dose (or concentration) and
effect: fitting sigmoidal curves, estimating EC50/IC50 with proper uncertainty, testing drug
combinations for synergy, and benchmark-dose modeling for toxicology. It applies from cell
culture to clinical trials — the math is the same, the interpretation differs.
## When to use
- Fitting concentration-response curves: EC50/IC50, Emax, Hill slope.
- Comparing potencies between compounds or conditions.
- Drug-combination synergy: Bliss, Loewe, Chou-Talalay, ZIP.
- Toxicology: benchmark dose (BMD) modeling, NOAEL vs BMD.
- Clinical dose-response: Emax models on trial data.