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pkpd-modeling

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Pharmacokinetic/pharmacodynamic modeling — compartmental models, nonlinear mixed effects, and dose selection.

skills/pkpd-modeling/SKILL.md

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Repository stars (not skill ratings): 56
Repository last updated: Oct 10, 2026
License: MIT

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## Overview

pkpd-modeling covers quantitative models linking drug dose to concentration (pharmacokinetics)
and concentration to effect (pharmacodynamics): compartmental models, nonlinear mixed-effects
(population) modeling, and model-informed dose selection. It is the quantitative backbone of
drug development — from first-in-human dose to label dosing recommendations.

## When to use

- Characterizing PK: absorption, distribution, metabolism, excretion from concentration-time
  data.
- Population PK (nonlinear mixed effects): separating inter-individual variability from residual
  error, identifying covariates (weight, renal function, genetics).
- PK/PD linkage: Emax models relating exposure to efficacy or safety endpoints.