Individual skill
drug-repurposing
Systematic drug repurposing — computational screening, evidence triangulation, and validation strategy.
skills/drug-repurposing/SKILL.md
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- License
- MIT
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## Overview
drug-repurposing covers the systematic search for new uses of existing drugs: computational
prediction (signature matching, network approaches, structure-based), evidence triangulation
across data types, and the validation path from prediction to clinical testing. Repurposing is
attractive (known safety, faster trials) but littered with false positives — the skill is about
separating plausible candidates from computational noise.
## When to use
- Generating repurposing hypotheses for a disease or target.
- Signature-based screening: disease signatures reversed by drug signatures (Connectivity Map
logic).
- Network-based repurposing: drug-target-disease networks, proximity measures.