Individual skill
acmg-variant-classifier
ACMG/AMP variant classification skill for systematic pathogenicity assessment
library/specializations/domains/science/bioinformatics/skills/acmg-variant-classifier/SKILL.md
Source commit feb68abe397acc14f32b34984975c48fedba2b33
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- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- Yes
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Network or broad shell
- Last checked
- Nov 9, 2026
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Repository context
- Repository stars (not skill ratings)
- 1,902
- Repository last updated
- Nov 1, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- agent-orchestration Repository topic
- agent-skills Repository topic
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- variant-analysis Declared skill tag
- acmg Declared skill tag
- clinical Declared skill tag
- pathogenicity Declared skill tag
- engineering Derived category
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SKILL.mdcore · 1,580 bytes
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# ACMG Variant Classifier Skill
## Purpose
Enable ACMG/AMP variant classification for systematic pathogenicity assessment following clinical guidelines.
## Capabilities
- Automated evidence criteria application
- Population frequency filtering
- In silico prediction integration
- Literature evidence curation
- Inheritance pattern analysis
- Classification report generation
## Usage Guidelines