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opentargets-database

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

backend/cli/skills/databases/opentargets-database/SKILL.md

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# Open Targets Database

## Overview

The Open Targets Platform is a comprehensive resource for systematic identification and prioritization of potential therapeutic drug targets. It integrates publicly available datasets including human genetics, omics, literature, and chemical data to build and score target-disease associations.

**Key capabilities:**
- Query target (gene) annotations including tractability, safety, expression
- Search for disease-target associations with evidence scores
- Retrieve evidence from multiple data types (genetics, pathways, literature, etc.)
- Find known drugs for diseases and their mechanisms
- Access drug information including clinical trial phases and adverse events
- Evaluate target druggability and therapeutic potential