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ensembl-database

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.

backend/cli/skills/databases/ensembl-database/SKILL.md

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# Ensembl Database

## Overview

Access and query the Ensembl genome database, a comprehensive resource for vertebrate genomic data maintained by EMBL-EBI. The database provides gene annotations, sequences, variants, regulatory information, and comparative genomics data for over 250 species. Current release is 115 (September 2025).

## When to Use This Skill

This skill should be used when:

- Querying gene information by symbol or Ensembl ID
- Retrieving DNA, transcript, or protein sequences
- Analyzing genetic variants using the Variant Effect Predictor (VEP)
- Finding orthologs and paralogs across species