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depmap

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    # DepMap — Cancer Dependency Map Skill Summary

## Overview
This skill enables querying the Cancer Dependency Map project from the Broad Institute to analyze genetic dependencies across cancer cell lines using CRISPR screens, RNAi, and compound sensitivity data.

## Primary Use Cases
The skill supports identifying cancer-selective gene dependencies, validating oncology drug targets, discovering synthetic lethal interactions, and uncovering biomarkers that predict treatment sensitivity.

## Core Data Types

**Dependency Scores:**
- Chronos (CRISPR): ranges ~-3 to 0+, where more negative indicates higher essentiality
- Standard thresholds: ≤-0.5 suggests dependence; ≤-1 indicates strong dependence
- Gene Effect: normalized version where -1 represents median effect of common essential genes