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biopython

Provides Biopython (Bio.Seq, Bio.SeqIO, Bio.Align, Bio.Entrez, Bio.Blast, Bio.PDB, Bio.Phylo, Bio.motifs, Bio.SeqUtils, Bio.Restriction) for sequence handling, file parsing, NCBI access, BLAST, structures, and phylogenetic trees in Python. Reads, writes, and converts FASTA, GenBank, FASTQ, PDB, mmCIF, Newick, and NEXUS files. Use when manipulating or translating DNA, RNA, or protein sequences, converting sequence file formats, fetching records from NCBI via Entrez, running or parsing BLAST searches, doing pairwise or multiple sequence alignment, analyzing PDB structures, or building and editing phylogenetic trees. For quick lookups use gget; for multi-service integration use bioservices.

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Nov 6, 2026
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Apache-2.0

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# Biopython: Computational Molecular Biology in Python

## Overview

Biopython is a comprehensive set of freely available Python tools for biological computation. It provides functionality for sequence manipulation, file I/O, database access, structural bioinformatics, phylogenetics, and many other bioinformatics tasks. The current version is **Biopython 1.87** (released 30 March 2026). It supports **Python 3.10-3.14** and PyPy3.10, and requires NumPy. Biopython 1.87 also addresses **CVE-2025-68463** in `Bio.Entrez.Parser` when parsing untrusted files, so prefer 1.87+ for workflows that parse externally supplied Entrez XML.

## When to Use This Skill

Use this skill when:

- Working with biological sequences (DNA, RNA, or protein)
- Reading, writing, or converting biological file formats (FASTA, GenBank, FASTQ, PDB, mmCIF, etc.)
- Accessing NCBI databases (GenBank, PubMed, Protein, Gene, etc.) via Entrez
- Running BLAST searches or parsing BLAST results