Individual skill
scikit-bio
Python library scikit-bio for biological sequence and community-ecology analysis: DNA/RNA/protein sequences, pair_align alignment, phylogenetic trees (NJ, UPGMA, GME/BME, Newick), alpha/beta diversity including Faith's PD and UniFrac, PCoA/CCA/RDA ordination, PERMANOVA/ANOSIM/Mantel tests, ancom and dirmult differential abundance, BIOM tables, and FASTA/FASTQ/GenBank I/O. Use when computing microbiome diversity from a BIOM or feature table. Use when running PCoA and PERMANOVA on a distance matrix. Use when building or comparing phylogenetic trees from sequences. Use when reading, converting, or aligning FASTA/FASTQ/GenBank/Newick data. Use when testing differential abundance in compositional count data. Not for general-purpose sequence scripting where Biopython is enough.
plugins/KalarisLabs/research-agent-skills/skills/scikit-bio/SKILL.md
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- Last checked
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- Nov 6, 2026
- License
- Apache-2.0
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# scikit-bio
## Overview
scikit-bio is a comprehensive Python library for working with biological data. Apply this skill for bioinformatics analyses spanning sequence manipulation, alignment, phylogenetics, microbial ecology, and multivariate statistics.
## When to Use This Skill
This skill should be used when the user:
- Works with biological sequences (DNA, RNA, protein)
- Needs to read/write biological file formats (FASTA, FASTQ, GenBank, Newick, BIOM, etc.)
- Performs sequence alignments or searches for motifs
- Constructs or analyzes phylogenetic trees
- Calculates diversity metrics (alpha/beta diversity, UniFrac distances)