Individual skill
clinical-variant-reporter
Classify germline variants from VCF/BCF files according to the ACMG/AMP 2015 28-criteria evidence framework and generate clinical-grade interpretation reports with per-variant evidence audit trails and ACMG SF v3.2 secondary findings screening.
skills/clinical-variant-reporter/SKILL.md
Source commit df61706c3e32fea21ad88f5b8a5189c895f9524d
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- No
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Not checked yet
- Last checked
- Nov 8, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
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Repository context
- Repository stars (not skill ratings)
- 1,175
- Repository last updated
- Nov 7, 2026
- License
- NOASSERTION
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- ai-agents Repository topic
- bioinformatics Repository topic
- equity Repository topic
- genomics Repository topic
- local-first Repository topic
- openclaw Repository topic
- population-genetics Repository topic
- reproducibility Repository topic
- acmg Declared skill tag
- variant-classification Declared skill tag
- clinical-genomics Declared skill tag
- pathogenicity Declared skill tag
- germline Declared skill tag
- secondary-findings Declared skill tag
- exome Declared skill tag
- genome Declared skill tag
- security Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Browse files
SKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesSKILL.mdcore · 16,594 bytesacmg_engine.pyruns · 24,539 bytesclinical_variant_reporter.pyruns · 41,062 bytesexample_data/demo_evidence_cache.jsonasset · 11,415 bytesexample_data/giab_acmg_panel.vcfasset · 2,818 bytesself_audit.pyruns · 9,542 bytestests/__init__.pyruns · 34 bytestests/test_clinical_variant_reporter.pyruns · 67,580 bytestests/test_self_audit.pyruns · 7,714 bytes
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