Individual skill

methylation-aggregation

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data into tissue-level methylation profiles. Handles coverage filtering, identifies hypomethylated regions (HMRs) and partially methylated domains (PMDs), and manages cross-lab variation.

skills/methylation-aggregation/SKILL.md

Source commit 36836c8725fd4d20d9c851ce314f5151aea5f57c

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Yes

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Yes

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No

Observed behavior

Network or broad shell

Last checked

Nov 6, 2026

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