Individual skill

hic-aggregation

Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolution-aware anchor matching, cross-lab variation, and Hi-C-specific quality metrics.

plugin/skills/hic-aggregation/SKILL.md

Source commit 36836c8725fd4d20d9c851ce314f5151aea5f57c

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Observed behavior

Network or broad shell

Last checked

Nov 6, 2026

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