Individual skill

gnomad-variants

Query gnomAD (Genome Aggregation Database) for population allele frequencies, gene constraint scores, and variant annotations to interpret ENCODE regulatory variants. Use when the user needs allele frequencies for variants in ENCODE regulatory elements, wants to assess gene constraint (pLI, LOEUF) for ENCODE target genes, needs population-specific frequencies for GWAS variants overlapping cCREs, wants to filter variants by rarity before functional annotation, or is interpreting ENCODE CRISPR/MPRA results in the context of population genetics. Also use when the user mentions gnomAD, allele frequency, pLI, LOEUF, constraint, rare variants, population frequency, ExAC, or variant filtering.

plugin/skills/gnomad-variants/SKILL.md

Source commit 36836c8725fd4d20d9c851ce314f5151aea5f57c

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Matches the observed repository HEAD

Yes

Scanner rules are current

Yes

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No

Observed behavior

Network or broad shell

Last checked

Nov 6, 2026

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