Individual skill

evo2

Score, embed, and generate DNA sequences with Evo 2, a long-context genomic foundation model. Use this skill when: (1) Computing per-nucleotide or per-sequence likelihoods for variant effect scoring, (2) Embedding genomic windows for downstream classification, (3) Generating DNA conditioned on a prefix, (4) Scoring regulatory or coding regions across species.

resources/skills/evo2/SKILL.md

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Nov 7, 2026
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Apache-2.0

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# Evo 2 — DNA Language Model

## Prerequisites

| Requirement | Minimum         | Recommended  |
| ----------- | --------------- | ------------ |
| Python      | 3.11            | 3.12 (<3.13) |
| CUDA        | 12.1+           | 12.4+        |
| GPU VRAM    | 24 GB (7B bf16) | 80 GB (40B)  |
| RAM         | 32 GB           | 128 GB       |

## How to run

### Installation